- Title
- Targeting apoptotic pathways in melanoma
- Creator
- Hersey, Peter; Zhang, Xu Dong
- Relation
- Targeted Therapeutics in Melanoma p. 125-153
- Publisher Link
- http://dx.doi.org/10.1007/978-1-61779-407-0_9
- Publisher
- Humana Press
- Resource Type
- book chapter
- Date
- 2012
- Description
- Impairment of cell death is a key property of cancer cells. It follows that irrespective of the target of new therapies cell survival mechanisms will need to be overcome for the treatment to be effective. Considerable information is now available about the mechanisms responsible for cancer cell survival. These center largely on the Bcl-2 protein family and the inhibitor of apoptosis proteins. They are regulated by complex pathways that are often initiated by the oncogenic process. A number of new treatments that target the anti- and proapoptotic proteins are at various stages of development and evaluation. In addition, there is an ever-increasing number of agents that target signal pathways involved in regulation of these protein families and which may have potent apoptosis-inducing activities. Complex feedback mechanisms initiated by these treatments as well as the inherent variability of melanoma cells are obstacles that remain to be overcome. Nevertheless, they would appear to be an essential component of future treatment strategies against melanoma.
- Subject
- melanoma; apoptosis; Bcl-2 family; BH3 mimetics; inhibitors of apoptosis proteins combination treatment
- Identifier
- http://hdl.handle.net/1959.13/1328013
- Identifier
- uon:25800
- Identifier
- ISBN:9781617794063
- Language
- eng
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